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阿片受体与神经细胞内Ca^(2+) 被引量：1

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摘要 阿片受体包括κ ,μ ,δ等多种亚型 ,属G蛋白偶联受体 ,广泛分布于神经系统。阿片受体可通过与神经细胞内第二信使Ca2 + 偶联 ,调节神经细胞的功能。κ ,δ阿片受体被激活后对神经细胞Ca2 + 通道的作用存在双向性 ,即通过多种途径或不同方式 ,抑制或激活Ca2 + 通道。δ阿片受体激活后可动员细胞内钙库 ,引起钙库释放增加 ;在多种神经细胞上 ,μ阿片受体激活后可抑制高电压依赖钙通道 ,而对低电压钙通道无明显影响。
作者 谢燕 余争平
机构地区 第三军医大学预防医学系劳动卫生教研室
出处 《国外医学（生理病理科学与临床分册）》 2002年第1期73-75,共3页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
基金 国家自然科学基金 :3980 0 39
关键词 阿片受体 神经系统 CA^2+通道 信号转导
分类号 R329.2 [医药卫生—人体解剖和组织胚胎学] R338.2 [医药卫生—人体生理学]
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参考文献22

  • 1Endoh T, Suzuki T. The regulating manner of opioid receptors of distinct types of calcium channels in hamster submandibular ganglion cells[J].Arch Oral Biol, 1998, 43(3):221-233.
  • 2Su X, Wachtel RE,Gebbart GF, et al.Inhibition of calcium currents in rat colon sensory neurons by K-but not mu-or delta-opioids[J].Neurophysiol, 1998,80(6) :3112 - 3119.
  • 3Ora K,Mikhal G,Yosef S, et al. Potentiation of transmitter release from NMB human neuroblastoma cells by kappa-opioids in mediated by N-type voltage-dependent calcium channels[J]. Brain Res, 1999,843:193.
  • 4Hu WH,Zhang, Yang HF, et al. Mechanism of the dynorphin-induced dualistic effect on free intracellular Ca2+ concentration in cultured rat spinal neurons[J].Eur J Pharmacol, 1998,342(2-3):325-332.
  • 5Hauser KF, Foldes JK, TTurbek CS.Dynorphin A (1-13) neurotoxicity in vitro: opioid and non-opioid mechanisms in mouse spinal cord neurons [J].Exp neurol,1999,160(2):361-375.
  • 6Soldo BL, Moises HC . Mu-opioid receptor activation inhibits N-and Ptype Ca2+ channel currents in magnocellular neurones of the rat supraoptic muclens[J]. J Physiol, 1998,513(3):787-804.
  • 7Endo K, Yawo H.Mu-Opioid receptor inhibits N-type Ca2+ channels in the calyx presynaptic terminal of the embryonic chick ciliary ganglion [J]. J Physiol, 2000,524(3):769-781.
  • 8Wandless AL,Smart D,Lambert DG.Mu-Opioid receptor activation decreases N-type Ca2+ current in magnocellular neurons of the rat basal forebrain[J].Brain Res,1997,758(1-2):118-126.
  • 9Kim CJ,Rhee JS, Akasike N.Modulation of high-voltage activated Ca2+channels in the rat periaqueductal gray neurons by mu-type opioid agonist [J]. J Neurophysiol,1997,77(3):1418-1424.
  • 10Connor M,Schuller A,Pintar JE,et al.Mu-opioid receptor modulation of calcium channel current in periaqueductal grey neurons from C57B16/J mice and mutant mice lacking MOR-1[J].Br J Pharmacol, 1999,126(7): 1553-1558.

同被引文献12

  • 1张香桐.丘脑在针刺镇痛中的整合作用[J].中国科学,1973,16:25-62.
  • 2Paxinos G, Watson C, eds. The rat brain in stereotaxic coordinates, 2nd edn. New York : Plenum Press, 1986. F33-35.
  • 3Meller ST, Gebhart GF. A critical review of the afferent pathways and the potential chemical mediators involved in cardiac pain. Neuroscience,.1992,48:501-524.
  • 4Janig W. Neurobiology of visceral afferent neurons: neuroanatomy, functions, organ regulations and sensations. Biol Psychol, 1996,42 (1-2) : 29-51.
  • 5Crea F, Gaspardone A. New look to an old symptom: angina pectoris.Circulation, 1997,96: 10-18.
  • 6Rosen SD, Camiei PG. The brain-heart axis in the perception of cardiac pain : the elusive link between ischaemia and pain. Ann Med, 2000,32 :350-364.
  • 7Rosen SD, Paulesu E, Frith CD, et al. Central nervous pathways mediating angina pectoris. Lancet, 1994,344: 147-150.
  • 8Lenz FA, Gracely RH, Hope EJ, et al. The sensation of angina can be evoked by stimulation of the human thalamus. Pain, 1994,59 : 119-125.
  • 9Ruggiero DA, Anwar S, Kim J, et al. Visceral afferent pathways to the thalamus and olfactory tubercle:behavioral implications. Brain Res, 1998,799: 159-171.
  • 10Blair RW, Ammons WS, Foreman RD. Responses of thoracic spinothalamic and spinoreticular cells to coronary artery occlusion. J Neurophysiol, 1984,51 : 636-648.

引证文献1

国外医学（生理病理科学与临床分册）
2002年 第1期

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