摘要
目的 评价1 8F 脱氧葡萄糖 (FDG)双探头符合线路断层显像 (DHTC)对非小细胞肺癌(NSCLC)患者淋巴结转移及其分期的可行性 ,并与CT结果进行对比。方法 15 9例确诊为NSCLC患者均在 2周内完成FDGDHTC和CT检查 ,1个月内完成外科手术后进行病理检查或纵隔镜、穿刺活组织检查等 ,以判断有无淋巴结转移。FDGDHTC和CT检查结果均与最终病理检查结果比较。结果15 9例NSCLC患者中 10 3例有淋巴结转移。FDGDHTC检查的灵敏度、特异性和准确性 (分别为 91% ,98%和 94% )均较CT(分别为 82 % ,6 4%和 75 % )高。在淋巴结转移的分期评估中 ,FDGDHTC低估 10例 (6 % ) ,仅 1例 (0 6 % )高估 ;而CT则高估 2 3例 (14% ) ,低估 2 1例 (13% )。结论 FDGDHTC用于NSCLC患者纵隔淋巴结转移及其分期是一可靠的非创伤性方法。
Objective To assess the feasibility of lymph node staging of non-small-cell lung cancer (NSCLC) with fluorodeoxyglucose (FDG) using a dual-head tomography with coincidence (DHTC) and to compare this technique with CT. Methods 159 patients (age range, 33～80 years) with diagnosed NSCLC were studied. In all patients, FDG DHTC, CT and thoracotomy or mediastinoscopy were performed within 1 month of each other. The histological examination of lymph nodes sampled from thoracotomy or mediastinoscopy and (or) biopsy was used as the standard for mediastinal staging. Results 103 of 159 patients were found with lymph node tumour metastases. The sensitivity, specificity and accuracy were 91%, 98% and 94%, respectively, for FDG DHTC and 82%, 64% and 75%, respectively, for CT. FDG DHTC showed a significantly higher sensitivity ( P< 0.05), specificity (P <0.005) and accuracy ( P< 0.005) than CT. For the assessment of lymph node involvement, 10 (6%) of the patients studied were under-staged and only 1 (0.6%) was over-staged with FDG DHTC but 23 (14%) were over-staged and 21 (13%) were under-staged with CT. Conclusions FDG DHTC is superior to CT for mediastinal lymph node staging in patients with NSCLC. Both the high negtive and positive predictive values of FDG DHCT are valuable for selecting patients for surgery.
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2002年第1期26-27,共2页
Chinese Journal of Nuclear Medicine
