摘要
目的 了解人工饲养条件下恒河猴脏器自发病变的发生情况 ,建立恒河猴自发病变的病理图谱。方法 采用常规组织学技术结合特殊染色方法 ,研究了包括各个年龄阶段的 70只恒河猴肝脏的组织病理变化。结果 发现 94 3%的猴肝脏存在不同程度的病变 ,包括实质细胞的各种变性、不同程度的坏死和增生 ,结缔组织的增生和纤维化 ,炎性细胞浸润 ,脓肿、囊肿等共 2 3种病变。肝脏病变程度和病变发生率与年龄密切相关而与性别无关 ,同一个体肝脏病变的种类数随年龄增长而增加。结论 应加强实验动物组织学病变的病理监测 。
Objective To study the liver spontaneous lesions of macaca mulatta in breeding.Methods Liver samples of macaca mulatta aged 2\|20 years, were observed by routine histological technique.Results Various spontaneous lesions, totaling 23 kinds in different degrees, were found in 94.3% monkeys of the study, including hepatocyte degenerations, necroses, and proliferations, connective fiber proliferations and fibrosis, inflammatory cell infiltration, abscess and cystis. The degree and the freqency of lesions increased with age, but no difference with sex. Usually several kinds of lesions occurred in one liver.Conclusion Histopathology of spontaneous lesions should be monitored so as to provide information for safety assessment of new medicine.
出处
《中国实验动物学杂志》
2002年第1期24-27,共4页
Chinese Journal of Laboratory Animal Science
基金
国家"九五"重点科技项目 ( 96 -A -2 3-0 6 -0 6 )
广东省重点科技攻关项目 ( 1998年第 12批 )
