摘要
目的:探讨E-钙粘素(E-Cd)及p53在壶腹周围癌中的表达,及与壶腹周围癌的分化、浸润及转移的关系。方法:采用免疫组化S-P法检测44例壶腹周围癌组织和11例炎性壶腹部粘膜组织E-钙粘素及p53的表达。结果:(1)77.3％(34/44)壶腹周围癌E-Cd异常表达,86.7％的中、低分化肿瘤(13/15)E-Cd表达异常,浸润范围广泛的肿瘤有81.8％(27/33)E-Cd表达异常,有转移的肿瘤中81.25％(13/16)E-Cd表达异常。(2)38.6％(17/44)壶腹周围癌p53阳性表达。(3)p53阳性表达肿瘤76.5％E-Cd异常表达,其中69.2％肿瘤浸润范围广泛。结论:(1)E-Cd表达异常是壶腹周围上皮性恶性肿瘤的恶性表型之一,且其异常表达率较高,E-Cd表达异常与壶腹周围癌的分化、浸润及转移有关。(2)p53表达一定程上反映了进展期肿瘤的侵袭能力。(3)E-Cd及p53的联合检测可能有助于壶腹周围癌的预后推测。
Objective: To study the relationship between expressions of E-cadherin (E-Cd) and p53 and differentiation, infiltration and metastasis of peri-ampullar carcinoma. Methods: Immunohistochemical technique (S-P method) was applied to detect the expression of E-Cd in 44 cases of peri-ampullar carcinoma and 11 cases of inflammatory ampullar mucosa tissues. Results: (1) The abnormal rate of E-Cd expression in 44 cases of peri-ampullar carcinoma was 77.3 % (34/44); that of tumors whose differentiation were middle or low was 86.7%(13/15); that of tumors which had a wide range of infiltration was 81.8% (27/33); that of tumors which had a metastasis was 81.25% (13/16). (2)The positive rate of p53 expression in 44 cases of peri-ampullar carcinoma was 38.6% (17/44). (3)The abnormal rate of E-Cd expression in cases that had positive expression of p53 76.5% , 69.2% of which had a wide range of infiltration. Conclusion: (1) The abnormal E-Cd expression is one of malignant phenotypes of peri-ampullar carcinoma and is related to differentiation, infiltration and metastasis. Its rate is high. (2) The expression of p53 reflects the invasive ability of tumors in progressive stage to a certain extent. (3) The combined examination of E-Cd and p53 may be conducive to guess the prognosis of peri-ampullar carcino-
出处
《天津医药》
CAS
北大核心
2002年第1期17-19,共3页
Tianjin Medical Journal
