摘要
目的 :观察 2种四联疗法作为二线方案根除幽门螺杆菌 (Hp)感染的疗效。方法 :10 8例经以质子泵抑制药为基础的三联疗法根除Hp失败或根除后复发的病人 ,分为A组 5 4例和B组 5 4例。 2组均予奥美拉唑 2 0mg、胶体次枸椽酸铋 2 4 0mg及甲硝唑 4 0 0mg ,po ,bid ,A组加四环素 5 0 0mg ,po ,qid ;B组加阿莫西林 10 0 0mg ,po ,bid ;疗程均为 7d。疗程结束 1mo后复查Hp。结果 :A ,B 2组Hp根除率按方案分析分别为 82 % (42 / 5 1)和 81%(42 / 5 2 ) ,按意图治疗分析均为 78% (42 / 5 4)。 2组不良反应发生率分别为 2 3% (15 / 5 3)和 11% (6 /5 3)。 2组间疗效比较差异无显著意义 (P >0 .0 5 )。结论 :2种四联疗法作为二线方案根除幽门螺杆菌均有良好的疗效 ,且疗效相近 。
AIM: To determine efficacy of two quadruple therapies as second line regimens for eradication of Helicobacter pylori (Hp) . METHODS: One hundred and eight patients who had failed eradication after proton pump inhibitor (PPI) based triple therapy or had relapsed after eradication, were divided into two groups. Group A ( n =54, M 44, F 10; age 61 a± s 13 a) were treated for 1 wk with omeprazole 20 mg, colloidal bismuth subcitrate 240 mg, metronidazole 400 mg po , bid, tetracycline 500 mg po , qid. Group B( n =54, M 43, F 11; age 62 a±17 a) were treated for 1 wk with omeprazole 20 mg, colloidal bismuth subcirate 240 mg, amoxicillin 1 000 mg, metronidazole 400 mg, po , bid. One month after anti Hp therapy, tests of Hp were repeated. RESULTS: One patient was lost to follow up in group A and group B, respectively. Two patients in group A and one patient in group B stopped treatment because of adverse reactions. On the per protocol analysis, eradication rates of Hp were 82 % in group A and 81 % in group B. On the Intention to treat analysis, eradication rates of Hp were 78 % in group A and in group B, respectively. Adverse reaction rates were 23 % in group A and 11 % in group B. The results between group A and group B showed no significant difference. CONCLUSION: The two quadruple therapies as second line regimens for eradication of Hp are highly effective and without severe adverse reactions.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2002年第3期146-148,共3页
Chinese Journal of New Drugs and Clinical Remedies
关键词
药物疗法
幽门螺杆菌
四联疗法
HP根除
临床疗效
omeprazole
citric acid
bismuth
tetracycline
amoxicillin
metronidazole
drug therapy, combination
Helicobacter pylori
