摘要
目的 :验证施普善治疗缺血性卒中后早期恢复期的疗效及安全性。方法 :多中心双盲随机平行对照研究 ,其中施普善组 199例 ,给予 10 0mL的氯化钠注射液 ,内含 30mL施普善 ;对照组 185例 ,给予氯化钠注射液 10 0mL ,均iv ,gtt,qd× 2 8d。结果 :治疗后施普善组智力检查量表评分比治疗前提高 3.3分±s 0 .6分 ,与对照组 (提高 2 .3分± 0 .7分 )比较差异有显著意义 (P <0 .0 5 )。治疗期间 2组病人的不良反应差异无显著意义 (P >0 .0 5 )。结论
AIM: To evaluate the efficacy of Cerebrolysin in the treatment of early rehabilitation after ischemic stroke. METHODS: The study was a multicentre, double blind and paralled group design trial. The total of 389 patients, aged 45 80 a and suffering from early rehabilitation after ischemic stroke were randomly divided into two groups. In Cerebrolysin group 199 patients were given 0.9 % sodium chloride injection 100 mL containing Cerebrolysin 30 mL. Another 187 patients of control group were given 0.9 % sodium chloride injection both iv,gtt,qd for 28 d. RESULTS: After treatment, Cerebrolysin group showed better than the control group in the MMSE scores(3.3±0.6 vs 2.3±0.7)( P <0.05). Adverse reactions were not significantly different between the two groups( P >0.05). CONCLUSION: Cerebrolysin is effective in cognitive function in the treatment of early rehibilitation after ischemic stroke and has less adverse reaction.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2002年第3期133-136,共4页
Chinese Journal of New Drugs and Clinical Remedies
基金
国家医药管理局新药评审中心课题
关键词
缺血性脑卒中
施普善
早期恢复阶段
认知功能
临床试验
双盲法
Cerebrolysin
cerebral ischemia
cerebrovascular disorders
clinical trials phase IV
randomized controlled trials
double blind method
multicenter studies
