摘要
目的 研究儿童急性淋巴细胞白血病 (ALL)染色体变化 ,探讨其临床意义。方法 通过直接法或短期培养法对 4 0例ALL患儿骨髓细胞进行染色体分析并观察临床疗效。结果 4 0例ALL患儿染色体异常检出率 70 % (2 8/4 0 ) ,其中数目异常 5 0 % ,结构异常 35 .7% ,数目合并结构异常 14 .3% ,核型正常组及超二倍体组患儿缓解率高于亚二倍体组及假二倍体组 ,具有显著统计学意义 (P <0 .0 1) ,亚二倍体及t(9;2 2 )核型为预后不良因素。
Objective To analyze the chromosomal changes and its clinical significance in childhood acute lymphoblastic leukemia(ALL).Methods Bone marrow samples from 40 pretreated children with ALL were studied cytogenetically directly or after short term in vitro culture, and the clinical curative effect of the patients was observed.Results Chromosomal abnormalities were present in 70 % (28/40) cases, half of which were only numerical aberrations and 35.7 % cases were only structural aberrations. The complete remission rates in patients with normal and hyperdiploid karyotype were significantly higher than those with pseudodiploid and hypodiploid karyotype. The karyotype of hypodiploid or t(9;22) predicted worse prognosis.Conclusion Chromosomal analysis is significant for the prognosis and management in children with ALL.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2002年第1期25-26,共2页
Journal of Applied Clinical Pediatrics
