摘要
本文采用３Ｈ－ＴｄＲ掺入法，微量ＣＰＥ法及ＡＢＣ免疫染色对２６例中晚期原发性肝癌（ＰＨＣ）患者及３０名正常献血员外周血的ＩＬ－２、ＩＦＮ－γ活性及ＩＬ－２Ｒ表达检测分析发现，ＰＨＣ患者的ＩＬ－２ＩＦＮ－γ活性及ＩＬ－２Ｒ表达均显著低于正常人，且ＩＬ－２与ＩＦＮ－γ及ＩＦＮ－γ与ＩＬ－２Ｒ间呈显著正相关。表明ＰＨＣ患者细胞因子免疫调节网络可能存在严重抑制或紊乱，这可能与ＰＨＣ的形成和发展有关。作者认为，若能合理应用ＩＬ－２及ＩＦＮ－γ等生物反应调节剂来改善病人的细胞免疫状态，可能会取得较好的抗瘤效果。
Interleukin 2(IL-2), interferen-r(IFN-r) and IL-2 receptor(IL-2R) expression of 26 patients with primary hepatic carcinoma(PHC) were measuredby 3H-TdR uptake assay, cytopathic effect inhibition method and ABC staining. IL-2, IFN-r and IL-2R in the patients and the controls were observed. This study suggests that the immune suppres sion in the PHC patientsmmay be associated with pathogenesis of PHC and the immune state in the PHC patients may be improved by administration of the biological response modulators.
出处
《胃肠病学和肝病学杂志》
CAS
1995年第1期49-51,共3页
Chinese Journal of Gastroenterology and Hepatology
