摘要
本文通过观察羧乙基锗倍半氧化物对二甲基肼诱导的小鼠结肠隐窝上皮细胞微核和凋谢的影响,发现羧乙基锗倍半氧化物可降低结肠隐窝上皮细胞微核和凋谢数,并有剂量-效应关系.说明羧乙基锗倍半氧化物具有明显的拮抗微核和凋谢的作用.该方法可作为抗结肠致癌物的快速筛选试验.
The effect of Ge-132 (an organic Germanium compound) on micronuclei and apopto-sis in the colon crypt cells of mice induced by DMH(1, 2-dimethylhydrazine) was observed by means of oral administration of Ge-132. The result showed that Ge-132 may reduce the incidence of the micronuclei and apoptosis of the colon Ge-132 crypt cells induced by DMH.and this was dose dependent. The result indicate that Ge-132 has marked antagonistic effects on DMH induced micronuclei and apoptosis. This method may contribute to the short-term assay for anticolon carcinogens.
出处
《胃肠病学和肝病学杂志》
CAS
1992年第1期69-71,共3页
Chinese Journal of Gastroenterology and Hepatology
