摘要
采用免疫电镜技术对10例慢性活动性肝炎(CAH)的活检标本和3例正常肝的细胞外基质的Ⅲ、Ⅳ、Ⅵ型胶原,纤维连结蛋白(FN)和层粘蛋白(LM)进行了研究.结果发现:在CAH其迪氏腔中的Ⅲ、Ⅳ、Ⅵ型胶原,LM,FN和肝细胞之间的间隙内的FN均较正常肝增多.Ⅲ型胶原,LM和FN在CAH贮脂细胞内质网的阳性程度比正常增强.本文的结果提示迪氏腔是肝纤维化的始发部位,FN与纤维化的始发机制有关.贮脂细胞是肝纤维化时产生胶原的重要细胞.
An immunoelectronmicroscopic technique was used to study extracellular matrix-Ⅲ,Ⅳ,Ⅵ type collagen,fibronectin (FN)and laminin(LM) in 10 bioptic specimens of chronic active hepatitis (CAH) and 3 specimens of normal liver. The results showed that the amounts of Ⅲ, Ⅳ, Ⅵ,type collagen,LM and FN of Disse space and FN of intercellular space in CAH were more than those in normal liver. The positive degree of AM and FN in the fat storage cells in CAH were stronger than those in normal liver. These results indicated that Disse space is the first part of hepatic fibrosis.FN is relation to primary mechanism of hepatic fibrosis and storage cell is an important cell producing collagen in hepatic fibrosis.
出处
《胃肠病学和肝病学杂志》
CAS
1992年第1期18-21,共4页
Chinese Journal of Gastroenterology and Hepatology
关键词
免疫电镜
胶原间质
肝炎
肝硬变
Immunoelectronmicroscopy collagen mesenchyme hepatitis cirrhosis
