摘要
目的 :建立PAP(前列腺酸性磷酸酶 )活性测定方法 ,探讨血清PAP与F PSA的相关性及在辅助前列腺癌临床诊疗中的应用价值。方法 :以酒石酸为抑制剂 ,采用Johson&Johson诊断公司干化学ACP测定方法 ,以VITROS 75 0全自动分析仪测定 2 0例健康志愿者 ,2 2例前列腺增生患者 ,2 8例前列腺癌患者治疗前后PAP活性变化 ,并与F PSA测定结果比较。结果 :前例腺癌PAP和F PSA值均显著高于前列腺增生 (P <0 0 1) ,前列腺癌治疗后PAP和F PSA值明显下降 (P <0 0 1) ,前列腺增生患者PAP和F PSA值与健康人相比较无统计学变化 (P >0 0 5 )。结论 :动态测定前列腺癌患者治疗前后PAP变化对前列腺癌的辅助诊断和治疗监测具有重要临床应用价值 ,且该方法稳定 ,操作简单。快速 。
Objective:To study the clinical significance of prostate acid phosphatase(PAP) in prostate hyperplasia and prostate cancer Methods: An inhibiting method have been established by using L Tartrate and dry chemistry The changes of serum total acid phosphatase (ACP), PAP and free prostate specific antigen(F PSA) of 20 normal person, 22 prostate hyperplasia and 28 prostate cancer patient have been studied by using the established inhibiting method Results: Serum PAP activity and F PSA were higher in prostate cancer than in normal person and prostate hyperplasia ( P <0 01) The significance decrease of PAP and F PSA had been found after therapy in prostate cancer patients But there are no obvious difference between normal person and prostate hyperplasia ( P >0 05) Conclusions:The method to measuring serum PAP activity is stable and easy to operate It is suitable for clinical laboratory and also a useful tumor marker to help the diagnosis and following up the therapy of prostate cancer
出处
《军医进修学院学报》
CAS
2002年第1期61-63,共3页
Academic Journal of Pla Postgraduate Medical School
