摘要
目的 :探讨儿童口腔粘膜尖锐湿疣的病毒类型、传播途径、临床病理特点及预后等。方法 :回顾 6例被确诊为口腔粘膜尖锐湿疣患儿的临床特点及HE切片 ,并对其中 5例采用免疫组化染色及原位杂交检测人乳头状瘤病毒 (HPV)DNA。结果 :儿童口腔尖锐湿疣多发生在 2岁左右 ,发病部位多位于腭部 ,并且多数有家族感染史 ,镜下见棘层上部或角化层常出现灶性凹空细胞 ,免疫组化检测结果显示 5例HPV共同抗原全部阳性 ,5例中有 4例HPV16 18_E6阳性 ;原位杂交结果显示仅 1例HPV6和HPV11同时阳性 ,另 1例初发时HPV6阳性而复发后呈阴性。结论 :儿童口腔尖锐湿疣的病毒类型。
Objective: The aim of this study is to study genotype, transmission, clinical and pathological characteristics, and prognosis of oral condyloma acuminate (CA) in children.Methods: The authors retrospected the clinical characteristics and slices of HE staining of six cases which have been diagnosed as oral CA and, performed immunohistochemistry (IHC) and in situ hybridization (ISH) analysis to detect the DNA of human papilloma virus in 5 cases.Results: Oral CA often happened in the hard or soft plates of children of two_year_old. Most of them came from the families had been infected by human papilloma virus (HPV). Histological examination demonstrated that koilocytes were common in the upper spinous and corneal layers. HPV was detected in all cases. HPV16/18_E6 antigen was positive in 4 of 5 cases examined. The result of ISH only show one case was HPV6_ and HPV11_ positive, and the other case was HPV_positive, but HPV could not be detected when recurring.Conclusion: The pathogen leading to oral condyloma acuminate (CA) and the transmission way of children may be different from that of adults.
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
2002年第1期27-29,共3页
West China Journal of Stomatology
