摘要
观察慢性酒精刺激过程中大鼠伏核EEG及功率谱的变化 ,探索酒精依赖的神经机制。在伏核埋植记录电极后 ,给大鼠饮用 6 %酒精水溶液 30d。用脑电图机及计算机信号采集系统记录及分析饮酒期间及停饮后的伏核EEG及功率谱。结果表明 :在慢性饮酒过程中 ,α节律明显减小 ,散在的高幅慢活动δ波和θ波逐渐增多 ,功率谱分析表明δ频段功率百分比明显增加 ,而θ频段功率百分比明显减少 ,总功率减少。停饮后 ,出现棘波和棘慢综合波 ,并持续增多 ,δ频段功率百分比逐渐减少 ,而θ和α频段功率百分比逐渐增加 ,总功率增加 ,约在停饮 9～ 10d ,脑电逐渐恢复正常。提示 :伏核EEG和脑电功率谱的变化在一定程度上可反映慢性酒精刺激及撤除刺激对神经系统的影响。
To investigate the neural mechanism in the ethanol dependence, the alteration of the EEG and power spectra in rat nucleus accumbens (Nacc) on the chronic ethanol exposure and withdrawal was analysed. The animals were given the 6 % (V/V) ethanol as their water intake for 30 days, and the ethanol was replaced by tap water in the 31th day. Electrodes were implanted in the Nacc,and the EEG was recorded and analyzed in the different stages. In the rats of chronic exposure to ethanol,the alpha waves of EEG were significantly decreased,while the delta and theta waves were increased.The EEG power spectra analysis showed that the delta power was increased, while the theta power decreased. In the rats of withdrawal stage,spikes and spike slow waves were appeared in the EEG.The EEG power spectra analysis showed that the EEG frequency band had moved to the high frequency range, the delta power was decreased, but the alpha and the theta were increased.In the 9th to 10th day of the withdrawal, the EEG and their power spectra recovered to the control level. This study suggested that the alteration of EEG and power spectra could reflect the effects of chronic ethanol exposure and withdrawal on the central neurous system.
基金
江苏省自然科学基金 (13K970 5 2 )
