摘要
精神分裂症的流行病学研究提示了遗传因子的作用 ,但精神分裂症的分子遗传学研究至今尚未发现导致该病的主要的、特异性的基因。连锁 ( linkage)和关联 ( association)研究几乎都得出阴性或有争议的结果 ,这些研究主要涉及某些侯选基因 ,如多巴胺受体基因和其它脑神经递质基因 ,目前 ,有些侯选基因已被排除作为精神分裂症的特异性病因学因素。最近大多数实验结果提示 :精神分裂症的遗传易感性极可能是多基因的 ,其作用效果依赖于生理、心理。
The epidemiological studies of schizophrenia have suggested that the genetic factors play a important role in schizophrenia.However recent molecular genetic studies of schizophrenia have,until now,been unable to demonstrate any specific major gene for schizophrenia.On the contrary,linkage and association studies have yielded almost exclusively negative or contradictory results.Such studies have involved certain candidate genes,such as the genes for dopamine receptors and other brain neurotransmitters.Some of these candidate genes have now actually been excluded as specific aetiological factors in schizophrenia.However, the most recent experimental evidences suggest that polygenes,acting together,could constitute a risk factor for schizophrenia.It is thus most probable that their effects are dependent on interaction with physical and psychosocial environmental factors.
出处
《健康心理学杂志》
2001年第6期403-406,共4页
Health Psychology Journal
