摘要
观察了32例重症肺心病 ADP 诱导的血小板聚集功能(简称 PA)和血液流变学,并和所测正常人、高血压病、冠心病、脑梗塞进行对比。结果:PA 测定值以肺心组最高,与正常人和其他组相比均有显著性差异(P<0.01);肺心组全血粘度和血球压积升高亦显著高于正常人和冠心组(P<0.01)。提示 PA 升高可促进高凝状态,DIC、微血栓形成和肺动脉高压。使用川芎嗪、丹参、肝素、心痛定等抗 PA 和抗凝药物,降低了病死率。
Platelet aggregate function (PA) induced by ADP in acute stage of thirty two cases with advanced cot pulmonale was determined.Hemor- heology and arterial blood gas were determined in these patients and compared with normal subjects,pationts with primary hypertension, coronary heart disease and cerebral infarction. It was found that the average values of PA in patients with cor pul were obviously higher than those in other groups.There were highly significant differences statistically (P<0.001)。 The variety of causes of PA increased with advanced cot pul,Pr- obably being related to hypoxemia acidosis,respiratory infection,hyper- viscosity and aging. These results showed that the imbalance of PGI/TXA with cot pul increased PA and may be responsible for blood coagulation DIC micro thromboembolism and pulmonary hypertension.We administered drugs with platelet inhibitor such as Liguatrajini,Dan sheng,Heparin Nifedi- pine and so on and the mortality was decreased.
出处
《江西医学院学报》
1989年第1期30-33,共4页
Acta Academiae Medicinae Jiangxi
关键词
肺原性心脏病
血小板聚集功能
血液流变学
重症
实验研究
platelet aggregation/drug effects
platelet function tests
hemodynamics
pulmonary heart disease/etiology
pulmonary heart disease/drug therapy
