摘要
黄芫花醇提物羊膜腔、宫腔给药对中期妊娠家兔引产有效;灌胃、阴道给药无效;静脉给药毒副反应明显,引产作用不确实。小鼠腹腔给药LD_(60)为3.0g/kg,95％可信限为2.8～3.2g/kg。有局部刺激性、致热反应及溶血作用,无抗原性。在一定的剂量范围内可加强大鼠离体子宫肌的收缩;家兔子宫排空完全,引出胎子为死胎。病理检查胎盘蜕膜细胞、绒毛膜滋养层细胞变性坏死。分离筛选得芫花酯甲为其有效单体之一。
Alcohol extract of Wikstroemia adminitrated by intrauterine or intra-amniotic injection resulted in termination for second-trimester pregnancy in rabbits, but no effect on termination of second-trimester pregnancy by oral and vaginal routes. No reliable effect was observed except for dramatic toxic reactions by intravenous injections. The LD_(50)(ip) in the mice was 3.0g/kg. Its reliability of 95％ was 2.8-3.2g/kg. The stimulating effect on the uterine muscle was very significant. The effect of uterine evacuation experiment in rabbits was reliable. Discharged fetus was died. The placental decidua cells and villi ceil degenerated with necrosis. Yuanhuacin was isolated from alcohol extract of Wikstroemia as one of the active constituents.
关键词
黄芫花
芫花酯甲
引产
毒性
成分
Wikstroemia
Yuanhuacin
termination of pregnancy
