摘要
用RIA法检测102例肝病患者及30名正常人的血清结合胆酸(CCA)。结果各组肝病患者CCA均值皆明显高于正常对照组(P<0.01)。急性黄疸型肝炎、肝硬化、慢性活动型肝炎和重症肝炎CCA试验的阳性率(91.7～100％)高于急性无黄疸型肝炎和慢性迁延型肝炎(分别为69.2％及57.1％)。慢性活动型肝炎、急性黄疸型肝炎和肝硬化患者有70～75％的患者CCA值大于正常值5倍以上,而慢性迁延型肝炎和急性无黄疸型肝炎仅有14.28％及15.38％的患者大于此值。作者认为,该项试验对于肝病的诊断和鉴别诊断都有一定的意义。
<ABSTRACT> The serum conjugated cholic acid(CCA) in 102 patients with liver diseases and30 normal subjects was determined by radioimmunoassay. The result showedthat average CCA level was significantly high in various groups of patientswith liver disease. The percentage of CCA positivity (91.7～100%) is higherin acute icteric hepatitis(AIH), cirrhosis, chronic active hepatitis(CAH) andse\ere hepatitis than in acute non-icteric hepatitis (ANIH) and chronic persistent hepatitis(CPH) (69.2% and 57.1% respectively). In 70～75% patientswith CAH, AIH or cirrhosis and 14.3～23.1% patients with CPH or ANIH, the CCA level increased five-fold over normal level. It is suggested that theserum CCA estimation is a sensitive liver function test for diagnosis anddifferential diagnosis of liver diseases.
关键词
肝炎
胆酸
血清
放射免疫测定
hepatitis
conjugated cholic acid
radioimmunoassay
