摘要
本文选用了特异性强、敏感度高的检测方法(SPRIA及ELISA),对经病理证实的55例慢性肝炎全部进行了血清HBV标志物的检测,其中41例并用斑点杂交法检测HBV-DNA,发现它除对乙型肝炎的诊断、病毒复制及临床预后等方面具有重要意义外,作者提出有些问题如对单项抗-HBs阳性、抗-HBs及抗-HBc双项阳性、抗-HBe阳性、PIISA受体及HBV-DNA等应予重视和重新评价。
<ABSTRACT> In this study, we report 55 cases of viral hepatitis examined with serologic HBV markers (HBVM) by means of SPRIA and ELISA. In 41 cases of them HBV-DNA were detected by spot hybridization. All cases were proved by transcutaneous liver biopsy. There were 34 cases of CPH, 20 CAH, and 1 AVH. There was a significant correlation between the liver biopsy and HBVM in chronic hepatitis. It is very important to decide the diagnosis and prognosis of hepatitis B and the replication of HBV. At the same time, we also found that some problems of HBVM, as anti-HBs(+), anti-HBS/anti-HBC (+), anti-HBe(+), PHSA-receptor and HBV-DNA, should be revisited and evaluated.
关键词
乙型肝炎
表面抗原
乙型肝炎病毒
chronic viral hepatitis
HBV markers (HBVM) liver biopsy
pathologic diagnosis
