摘要
目的 探讨药盒在晚期胃癌治疗中的临床价值。方法 无法外科手术的胃癌 18例 ,依据化疗途径不同分两组 :A组 10例 ,采用经皮经股动脉植入药盒 ,术后经药盒 1周或 2周化疗 1次 ,B组 8例 ,采用术中动脉插管化疗 ,每 1周或 2周化疗 1次。结果 A、B两组有效率 (CR +PR)分别为 5 0 %和 37 5 %(P <0 0 5 ) ,A组 6个月、1年、2年生存率分别为 10 0 %、5 0 %、2 0 %,B组分别为 75 %、37 5 %、12 5 %(P <0 0 1) ,A组患者的生存质量明显改善 ,消化道反应、肝胆骨髓毒性均较B组低。结论 经药盒间断性化疗治疗晚期胃癌可明显改善患者的生存质量 ,提高生存率。
Objective To study the efficacy of arterial infusion chemotherapy via drug delivery system(DDS). for advanced gastric cancer.Methods Hepatic arterial infusion chemotherapy was performed in 18 cases of gastric cancer with no indication for operation. The patients were divided into 2 groups as follows:①Group A, 10 patients were treated intra arterially once every 1 or 2 weeks, via-inplanted DDS.②Group B. 8 patients were treated intra-arterially once every 1 or 2 weeks via surgical implantations.Results The response rates(CR+PR) were 50% and 37.5% repectively in group A and B(P<0.05),the 0.5,1 and 2 year survival rates were 100%,50%,20%,respectively in group A, but 75%,37.5%,12.5% respectively in group B(P<0.01). Liver biliary gastrointestinal and bone marrow toxciey in group A patients was greatly lower than those in group B patients.Conclusion Intermittent arterial infusion chemotherapy via DDS significantly improves survival and quality of life in patients with advanced gastric cancer.
出处
《陕西肿瘤医学》
2002年第1期14-15,共2页
ShanXi Oncology Medicine
