摘要
目的 :探讨丙种球蛋白治疗小儿特发性血小板减少性紫癜 (ITP)的疗效。方法 :87例ITP患儿随机分成两组。丙种球蛋白组 (治疗组 ) 4 5例 ,40 0mg·kg-1,静脉注射 ,qd ,3d一个疗程 ;肾上腺皮质激素组 (对照组 ) 4 2例 ,按激素治疗常规剂量 ,疗程一般 <4周 ,两组其他用药相同。根据血小板恢复时间、出血症状控制时间 ,比较两组治疗后的临床疗效。结果 :治疗组较对照组血小板恢复时间、出血症状控制时间短 ,两组疗效经 χ2检验差异有显著性意义 (P <0 .0 1)。结论 :丙球治疗ITP起效快 ,对不同年龄患儿可迅速减轻各部位出血症状 ,避免大量出血危及生命 ,是治疗重症ITP的较好办法。
Objective: To explore a therapeutical effect of children with idiopathic thrombocytopenic purpura(ITP) treated with γ globulin. Method: 87 cases, who suffered from ITP, were divided into two groups. In γ globulin group(treated group), 45 cases received the intravenous γ globulin 400 mg·kg -1 , qd, for three days; in corticosterone group (controlled group), 42 cases received the routine dosage of corticosterone, for 4 weeks, the other drugs used were identical in both groups. The therapeutical effects of both groups were comparable according to recovering time of thrombocyte and controlled time of bleeding symptom. Results: The recovering time of thrombocyte and controlled time of bleeding symdrome in the treated group were shorter than that in the controlled group. The difference between the therapeutical effects of both groups showed the significant importance( P<0.01 ). Conclusion: The therapeutical effect with γ globulin begin rapidly, the bleeding symptoms of each site can be reduced rapidly in children of various age, profuse bleeding of threatening to life may be avoided. It is a better method for treating severe ITP.
出处
《药物流行病学杂志》
CAS
2001年第4期171-172,共2页
Chinese Journal of Pharmacoepidemiology
