摘要
目的探讨内皮素(ET)及降钙素基因相关肽(CGRP)在类风湿性关节炎(RA)发生、发展过程中的作用。方法采用放射免疫分析法,对30例RA患者及20例正常对照组血浆中ET及CGRP的水平进行检测。结果RA患者血浆中ET的水平及ET/CGRP的比值明显升高,CGRP水平明显降低,与正常对照组相比较差异显著(P<0.01)。进一步分析表明,活动期RA患者及关节X线改变为Ⅲ～Ⅳ期的RA患者,血浆ET的水平及ET/CGRP的比值明显高于稳定期及关节改变为Ⅰ～Ⅱ期的RA患者;而血浆CGRP的水平明显低于后者(P<0.01)。结论RA患者体内存在明显地ET及CGRP的平衡失调,且与RA患者的病情严重程度密切相关,提示ET及CGRP参与了RA的发病过程。
Aim To investigate the role of endothelin(ET)and calcitonin gene related peptide(CGRP)in rheumatoid arthritis(RA). Methods ET and CGRP Levels in 30 RA patients and 20 healthy controls were determined by radio-immunoassay. Results 1Plasma ET level and ET/CGRP ratio in RA patients were significantly higher than those in controls(P<0.01),while CGRP level obviously decreased(P<0.01);2Plasma ET and ET/CGRP ratio in active stage and Ⅲ-Ⅳ phase (X-ray change)RA patients were much higher than those in stable stage and Ⅰ-Ⅱ phase RA patients(P<0.01),while CGRP level in the former was lower than that in stable and Ⅰ-Ⅱ phase patients(P<0.01). Conclusion Imbalance between ET and CGRP was closely correlated with disease severity of RA. ET and CGRP may play an important role in etiology and pathogenesis of RA.
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2001年第6期531-532,共2页
Chinese Journal of Cellular and Molecular Immunology
