摘要
目的：研究β－榄香烯对2－乙酰氨基芴(2－AAF）诱发实验性鼠肝癌的干预效应，并探讨其对c－myc、c－erbB－2和血管内皮生长因子(VEGF）等蛋白表达的影响。方法：以2－AAF喂饲SD大鼠，制备肝癌模型，予以不同剂量榄香烯乳腹腔内注射，观察肿瘤生成状况，并测定c－myc、c－erbB－2和VEGF蛋白的表达。结果：小剂量榄香烯乳(5mg／kg）干预组发生肝癌结节数较其他组少；c－myc、c－erbB－2和VEGF在正常对照组均为阴性，而增生结节或癌结节均为阳性，其表达水平与榄香烯乳用量无关。结论：小剂量β－榄香烯对2－AAF诱发的实验性鼠肝癌有一定阻抑作用，但不是通过调控c－myc、 c－erbB－2和VEGF等基因蛋白实现的。
Objective： To study the intervention effects of β－elemene on experimental liver cancer induced by 2－acetamidofluorene (2－AAF) and on the expressions of c－myc， c－erbB－2 and vascular endothelial growth factor (VEGF) in livers． Methods： Animal model of liver cancer was established by feeding SD rats with 0．05％ 2－AAF， β－elemene of different doses were injected intraabdominally to observe the effects on occurrence of cancerous nodules and the expressions of c－myc， c－erbB－2 and VEGF were detected． Results： Cancerous nodules in the group of low dose β－elemene were less than in other groups the expressions of c－myc， c－erbB－2 and VEGF were negative in normal control group， but positive in proliferative and cancerous nodules and the expression levels were not correlated with the doses of β－elemene． Conclusion： β－elemene of low dose has some inhibitory effects on experimental liver cancer induced by 2－AAF and the intervention effects of β－elemene are not through regulation of c－myc， c－erbB－2 and VEGF
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2001年第8期614-617,共4页
Chinese Journal of Clinical Oncology
基金
江苏省南通市科委社会发展项目基金资助 (项目编号59831)
