摘要
1974年以来,我室试用棉酚男子避孕药255例,发生低血钾性瘫痪24例,这些病例均发生在15mg和20mg的给药组,而当剂量减至12.5mg和10mg时,低血钾不再发生。低血钾性瘫痪病例,用补钾能迅速治愈。通过实验和临床研究表明,部分服醋酸棉酚20mg/天作为起效剂量的对象,服药2个月后开始出现尿NAG和/或β_2M增高以及同时发生肾性失钾。这表明棉酚可能引起近端肾小管损害。作者认为降低棉酚起效剂量或许是一个防止发生低血钾症的途径,而棉酚所致低血钾症是由于肾小管损害所致。
Since 1974,we have obseryed 255 volunteers taking part in clinical trial of gos-sypol as a male antifertility agent.In 24 cases hypokalemic paralysis occurred and waseffectively treated with potasium replacement.These cases all occurred in groups.withdaily loading dosage of 15 mg and 20 mg. when the dosage was reduced to 12.5 mg and1Omg,the hypokalemia did not occur again.Eased on laboratory and clincal stu-dies,some of the volunteers treated with a daily loading dosage of 20 mg,started tohave uriary N-acetyl-3-D-glucosaminidase (NAG) and/or beta 2-microgloulin(β_2M)increased with a simulaneous renal potassium loss after 2 months’treatment.Thatindicated that gossypol might induce proximal renal tubular damage.The authors believethat a decrease in the loading dose of gossypol might be an approach to avoid theoccurence of hypokalemia and that the cause of such hypokalemia is due to renaltubular damage.
出处
《生殖与避孕》
CAS
CSCD
北大核心
1991年第2期34-38,共5页
Reproduction and Contraception
关键词
棉酚
低血钾
肾小管损害
Gossypol
Hypokalemia
Renal tubular damage
