摘要
目的 :探讨大承气汤改善阳明腑实喘满证中肺通气功能和肺组织病变的机制。方法 :将实验家兔随机分为对照组、肺水肿模型组和大承气汤治疗组。从兔耳缘静脉注入油酸建立家兔实验性肺水肿模型。大承气汤由胃管灌入 ,观察动物一般情况 ,分析制模后 7小时和 3日肺形态学改变。结果 :油酸可以致家兔实验性肺水肿 ,以肺水肿、肺出血、毛细血管微血栓和肺泡内透明膜形成为主要标志。大承气汤具有改善肺水肿、促进肺泡上皮特别是 型上皮细胞增生、促进损伤修复的作用。结论 :大承气汤的治疗作用可能与其促进肺泡上皮增生特别是 型上皮细胞增生及修复、改善肺泡通气 /血流比等多种作用有关。
Objective:To investigate the mechanism of Dachengqi decoction(DCQT,大承气汤) on improving respiration function and pulmonary pathological change in the yangming visceral substantive and asthma syndrome (阳明腑实喘满症).Methods:Rabbits were randomly divided into control group,pulmonary edema model group and DCQT treated group.The pulmonary edema was established by injecting oleic acid,then treated with DCQT through gastric tube.Pulmonary morphology changes were observed 7 hours and 3 days after injection.Results:In model group,the important pathological changes were interstitial and intraalveolar edema,hemorrhage and thrombus in small pulmonary venules and hyaline membranes in the alveolar lumina.DCQT could improve above pathological changes,promote pneumocytes especially pneumocyte Ⅱ proliferation and reparation.Conclusions:The results indicate that the curative mechanism may be improving pneumocyte proliferation and reparation and ventilation/perfusion ratio.
出处
《中国中西医结合急救杂志》
CAS
2002年第1期24-26,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
上海市高等学校科技发展基金资助项目( No.2 0 0 0 Q94)
