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用博来霉素建立硬皮病动物模型及其应用 被引量:7

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摘要 硬皮病是一种可累及多个器官和脏器的结缔组织病,其确切的病因和发病机制尚不完全清楚,目前亦无理想的治疗药物和方法。建立合适的硬皮病的动物模型,对于阐明发病机制和遴选治疗药物具有非常重要的意义。文中就应用博来霉素注射实验鼠,建立硬皮病动物模型及其应用情况作了归纳。
出处 《国外医学(皮肤性病学分册)》 2001年第6期344-346,共3页 Foreign Medical Sciences(Section of Dermatology and Venereology)
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  • 1山本俊一强皮症モデルの応用皮膚病診瘵,2000,22(11):1014-1017.
  • 2Fisman S,Russo GG.The toxic pseudosclerodermas.Int J Derrmatol,1991,30(12):837-842.
  • 3Varga J,Jimenez SA.Chemical exposure-induced cutaneous fibrosis.ArchDermatol,1994,130(1):97-100.
  • 4Yamamoto T,Takagawa S,Katayama I,et al.Animal model of sclerotic skin.Ⅰ:Local injections of bleomycin induce sclerotic skin mimicking scleroderma.J Invest Dermatol,1999,112:456-462.
  • 5Yamamoto T.Takagawa S,Katayama I,et al.Anti-sclerotic effect oftransforming growth factor- β antibody in a mousee model of bleomycin induced scleroderma.Clin Immunol,1999,92(1):6-13.
  • 6Hunzelmann N,Anders S.Fierllbeck G,et al.Multicenter trial of 1 yearof treatment with recombinant interferon gamma.Arch Dermatol,1997,133(5):609-613.
  • 7Yamamoto T,Takagawa S,Kuroda M,et al.Effect of interferon-ron exper-imental scleroderma induced by bleomycin.Arch Dermatol,2000,292:362-365.
  • 8Black CM,Silman A J,Herrick AI,et al.Interferon-α does not improveoutcome at one year in patients with diffuse cutaneous scleroderma..Arthri-tis Rheum,1999,42:299-305.
  • 9Boeder WA,Noble NA.Transforming growth factor βin tissue fibrosis.N Engl J Med,1994,331(19):1286-1292.
  • 10Peltonen J,Kahari L,Jaakkola S,et al.Evaluation of transforming growth facter β and type Ⅰ procollagen gene expression in fibrotic skin dieases by situ hybridization.J Invest Dermatol,1990,94(3):365-371.

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