摘要
探讨抗肝昏肠液对肝性脑病大鼠白细胞介素6(IL-6)的影响。方法:采用药物诱导加结扎、切除2/3肝脏的方法建立大鼠肝性脑病模型,用抗肝昏肠液大、小剂量治疗的患者为治疗组,以乳果糖治疗的患者为对照组,观察药物对肝性脑病大鼠IL-6,脑电图、血氨、肝功能及肝组织病理学等的影响。结果:抗肝昏肠液大、小剂量对IL-6及其他指标都有不同程度的改善,大剂量组疗效优于乳果糖组。结论:抗肝昏肠液能显著降低IL-6含量。其影响可能与以下作用有关:①阻断肠道对氨、内毒素等有毒物质的吸收,促进其排除;②抑制单柱巨噬细胞系统介导的细胞毒作用;③促进肝功能恢复,行使对内毒素等的清除功能。从而抑制IL-6对肝脏进一步的免疫损伤,促进肝性脑病的复苏。
To study the effects of the Kangganhun enema (KGHE) on interleukin-6 (IL-6) in experimental hepatic encephalopathy (HE). Methods: The rats HE model were made with drug-induced, ligation and 2/3 liver tissue excision, treated with large dose, small dose of KGHE, compared with Lactulose. The changes of IL-6 electroencephalogram (EEG), blood ammonia (BA), hepatic function, liver tissue pathology etc. were observed. Results: IL-6 and the other indexes were improved by KGHE and Lactulose. Furthermore, curative effect of large dose of KGHE ex-celed Lactulose. Conclusion: The level of IL-6 were debased by KGHE observably. The effects relate with here after actions:①Blocking the toxicant such as ammonia, endotoxin etc. are absorbed by intestinal tract, promoting them cleared away; ②Inhibiting the cytotoxic function by mononuclear phagocytic system (MPS) - mediated ; ③Recovering liver function, promoting toxicant cleared away. So inhibiting immune injury to liver further from IL-6, promoting resuscitation of HE.
出处
《中西医结合肝病杂志》
CAS
2001年第5期289-291,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
基金
湖北省卫生厅科研项目(No:9809)
关键词
肝性脑病
肝昏肠液
白细胞介素6
大鼠
实验研究
Hepatic Encephalopathy Kangganhun Enema Interleukin-6 Rat Experimental Study
