摘要
目的 探讨隆突性皮肤纤维肉瘤的病理形态 ,免疫组化与肿瘤复发的关系。方法 采用HE和组织化学、免疫组化染色 ,对 48例隆突性皮肤纤维肉瘤进行病理学观察。结果 肿瘤组织学分为普通型、粘液型和纤维肉瘤型三个亚型。免疫组化标记 ,全部病例Vimentin和CD3 4呈弥散性阳性 ;p5 3、PCNA、Ki6 7阳性率分别为 3 3 3 %、6 6 7%和 5 0 %。结论 隆突性皮肤纤维肉瘤的病理分型、免疫组化p5 3、PCNA、Ki6 7标记对估计肿瘤的生物行为可能有指导意义。
Objective To explore the relationship among histological types,immunohistochemical staining and recurrence of dermatofihrosarcoma protuberans (DFSP).Methods A patients material was embedded in paraffin and had sections stained with HE,histochemistry and immunohistochemistry.Clinical and pathological analysis were done. Results forty-eight cases of tumors fell into the following groups:ordinary DFSP,myxoid DFSP and fibrosarcomapattern DFSP.Immunohistochemical staining showed that vimentin and CD34 were positive expression in all cases,the percentage of p53,PCNA and Ki67 positive expression were 33.3%,66.7% and 50%,respectively.Conclusions Histological types of DFSP and p53,PCNA,Ki67 expression in DFSP may serve as singnificant predicting factors for the prognosis of the patients.
出处
《河南肿瘤学杂志》
2001年第5期318-319,共2页
Henan Journal of Oncology
