摘要
目的 :初步探讨血浆 C型钠尿肽 (CNP)水平与高血压及左室肥厚程度的相关性。方法 :采用卒中易感型自发性高血压大鼠 (SHRSP) ,并与正常血压大鼠 (WKY)作对照 ,应用放射免疫方法检测 CNP水平。结果 :SHRSP组收缩压 (SBP)和反映左室肥厚的指标如左心室加室间隔 (L V+S)重量和 (L V+S) /体重 (BW)比值均明显高于 WKY组 (P<0 .0 1) ;SHRSP血浆 CNP水平 (145± 42 ng/ L)明显高于 WKY(72± 11ng/ L) ,差异非常显著 (P<0 .0 1) ;SHRSP血浆 CNP与 SBP,(L V+S) / BW均呈正相关 (P<0 .0 5 ) ,而 CNP与心率 (HR)、右心室 (RV)重量和 BW则未见明显相关性 (P>0 .0 5 )。结论 :血浆 CNP水平可以反映高血压及左室肥厚程度。
AIM:To investigate the correlations between plasma Type C natriuretic peptide(CNP) levels and the degree of hypertension and left ventricle hypertrophy in stroke-prone spontaneously hypertensive rats (SHR_ SP ). METHODS:The plasma concentrations of CNP were measured by means of radioimmunoassay in SHR_ SP and compared with those of normotensive rats (Wistar-Kyoto rat,WKY). RESUTLS:Systolic blood pressure (SBP) and left ventricle puls septum (LV+S) weight and (LV+S)/body weight (BW) ratio were markedly higher in SHR_ SP than in WKY (P<0.01). Plasma CNP levels were 145±42 ng/L and 72±11 ng/L in SHR_ SP and in WKY respectively,and the difference were significant (P<0.01). There were positive correlations between CNP and SBP as well as CNP and (LV+S)/BW (P<0.05),while CNP had no significant correlations with heart rate (HR),right ventricle (RV) weight and BW(P>0.05). CONCLUSION:CNP may reflex the degree of hypertension and left ventricle hypertrophy.
出处
《心脏杂志》
CAS
2001年第5期354-356,共3页
Chinese Heart Journal
基金
国家1035工程项目 ( No.96 90 10 10 1)
关键词
C型钠尿肽
高血压
心肌肥厚
自发性高血压大鼠
natriuretic peptide, Type C
hypertension
myocardial hypertrophy
spontaneously hypertensive rats
