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肾小球疾病患者外周血CD62P、CD63的变化及其临床意义 被引量:1

CLINICAL SIGNIFICANCE OF PERIPHERAL BLOOD CD62P, CD63 IN PATIENTS WITH GLOMERULAR DISEASE
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摘要 目的 :探讨慢性肾小球疾病患者外周血CD6 2P、CD6 3的表达及其临床意义。方法 :采用流式细胞技术对34例肾小球疾病患者外周血CD6 2P、CD6 3水平进行检测 ,以 16例正常人作对照。结果 :肾小球疾病各组患者CD6 2P、CD6 3水平均显著高于正常对照组 (P <0 .0 1) ;继发性肾小球疾病组CD6 2P、CD6 3表达水平明显高于原发性肾小球疾病组 ,差异有显著性 (P <0 .0 0 1)。结论 :CD6 2P、CD6 3在肾小球疾病的发生、发展中起重要作用。 Objective:To investigate the expression and significance of CD62P,CD63 in glomerular nephritis.Methods:The expression of CD62P and CD63 in blood of glomerular nephritis were assessed by flow cytometry,being compared with the control(P<0.001).Results:CD62P and CD63 levels in patients were higher than those in the control(P<0.001).Conclusions:Expression of CD62P and CD63 in patients with glonerular nephritis are abnomal.CD62P and CD63 might play an important role in progression of renal disease.
出处 《中国现代医学杂志》 CAS CSCD 2001年第11期60-60,62,共2页 China Journal of Modern Medicine
基金 兰州军区兰州总医院人才培养基金项目 编号RC -0 3
关键词 肾小球疾病 血小板 粘附分子 临床意义 Glomerular nephritis Platelet Adhesion molecule
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  • 1Joseph JE, Harrison P, MackieI J , et al. Increased circulating platelet- leucocyte complexes and platelet activation in patients with antiphospholipid syndrome, systemic lupus erythematosus and rheumatoid arthritis. Br J Haematol 2001;115:451 -459.
  • 2Nossent JC. SLICC/ACR damage index in Afro- Caribbean patients with systemic lupus erythematosus: changes in and relationship to disease activity, corticosteroid therapy, and prognosis. J Rheumatol 1998;25:277-284.
  • 3吴海波,郑加永,曾晓初.血小板膜糖蛋白CD62P CD63在2型糖尿病微血管并发症患者的表达及临床意义[J].黑龙江医学,2004,28(3):187-188. 被引量:2

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