摘要
观察腹水膏穴位贴敷对小鼠艾氏腹水癌的疗效 ,并从细胞因子角度探讨其治疗机理。采用艾氏腹水癌瘤株用NIH小鼠接种 ,随机分正常空白对照组 (正空组 )、模型对照组 (模对组 )、局部贴敷组 (局贴组 )、穴位贴敷组 (穴贴组 ) 4组进行观察研究。结果 ,与模对组相比 ,腹水膏局贴或穴贴均可显著延长荷瘤小鼠生存期 (P <0 0 5 ,P <0 0 1) ,显著抑制恶性腹水增长速度 (P <0 0 5 ,P <0 0 1) ,穴位贴敷优于局部贴敷 (P <0 0 5 ) ;腹水膏可下调外周血sIL 2R水平 (P <0 0 5 ) ,显著提高外周血TNF杀伤活性 (P <0 0 0 1)。艾氏腹水癌小鼠存在细胞因子网络的调节失衡 ,腹水膏治疗艾氏腹水癌疗效确切 ,其机理可能为下调外周血sIL 2R水平 ,提高外周血TNF杀伤活性 ,促进细胞免疫功能。
Objective :To investigate the machenism of Ascitis Plaster(AP) in mice bearing Ehrlich Ascites Carcinoma (EAC) by Acupoint sticking therapy. Method :40 NIH mice were randomly divided into 4 groups with different treatment and TNF and sIL 2R were used as indexes. Result :AP can prolong longevity of EAC mice ( P <0 05);markedly inhibit the growth of ascitis( P <0 05).Acupoint Application is better than local application in all above indexes( P <0 05).It is revealed that the disorder of cellular immunity among tumor bearing mice featured by high serum level of sIL 2R( P <0 05) and lower killing activity of serum TNF( P <0 05),comparing with that of normal mice.AP can significantly reduce the sIL 2R level( P <0 05) and enhance the killing activity of serum TNF among tumor bearing mice( P <0 05),comparing with that of control group. Conclusion :The therapeutic effect of AP in mice bearing EAC was definite.AP can regulate the disorder of sIL 2R and TNF so as to maintain the normal cellular immunity which led to the recrosis and apoptosis of EAC.
出处
《辽宁中医杂志》
CAS
2002年第2期118-120,共3页
Liaoning Journal of Traditional Chinese Medicine
