摘要
目的 :从基因水平对膀胱癌多重耐药基因 ( MDR1)进行研究。方法 :用 PCR技术对膀胱癌组织及正常膀胱组织进行分析检测。结果 :大多数膀胱癌及少数正常膀胱粘膜标本在 1 67bp处显示 MDR1基因异常扩增。结论 :随肿瘤分级的增高 ,MDR1表达率有增高趋势 。
Objective:In order to study on the reasons of failure in chemotherapy in the bladder cancer,multiple drug resistance gene MDR 1 were analyzed at the gene level.Methods:The bladder cancer tissue and normal bladder tissue were analyzed and examined by PCR technique.Results:The MDR 1was remarkably extended in the most bladder cancers and a few normal bladder mucous membrane specimen.The expression rate of MDR 1 was increased with the increasing class of the tumour.Conclusion:This sutdy suggested that the expression of MDR 1 gene was interrelated closely to the biologic activity of bladder cancer.The higher the bladder cancer differentiation,the higher the positive expression of MDR 1 in the bladder cancer tissue,the higher the failure rate of chemotherapy.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2002年第1期106-107,共2页
Journal of Jilin University：Medicine Edition
关键词
膀胱癌
多重耐药基因
PCR
bladder cancer
multiple drug resistance genes (MDR)
PCR
