摘要
目的 研究鼻咽癌患者的免疫功能状况和免疫治疗效果。方法 检测了 2 3例鼻咽癌患者外周血的NK细胞 ,IL 2、TNF α和T淋巴细胞亚群的浓度水平 ,并与 2 0例健康人作对比。用rIL 2对13例患者进行局部免疫治疗。 10例患者进行全身免疫治疗。结果 治疗前鼻咽癌患者的TNF α浓度水平与健康人相比 ,差别有非常显著的意义。IL 2的差别有显著的意义。而用rIL 2治疗前后 ,患者各项免疫指标比较差别均无显著意义。临床治疗效果 ,局部治疗部分缓解 (PR) 5例 (5 /13)不变 7例(NC) ,恶化的 1例 (PD)。全身用药患者的精神状况 ,体力有改善。但肿瘤的大小未见明显变化。结论 rIL
Objective In order to investigate the immunologic function and the effect of immunotherapy for nasopharyngeal carcinoma(NPC) patients.Methods The serum level of NK cell, IL 2. T subset in peripheral blood were assayed in 23 patients with NPC and in 20 healthy persons as control. 13 cases of NPC were treated with rIL 2 via intratumor injection, other 10 cases were using rIL 2 infusion.Results Serum level of TNF α in NPC patients were highest and IL 2 was higher than in healthy persons, between the two groups the difference is significant. But before and after the treatment above index of immunologic function in patients have no significant difference. The clinical results: 5 cases were achieved PR. 7 cases were NC and 1 case was PD in intratumor injection group. In other group the size of tumor didn't change, but the patients genegral condition has been improved. Conclusion Using rIL 2 local injection for NPC patients is effective.
出处
《陕西肿瘤医学》
2001年第2期93-94,69,共3页
ShanXi Oncology Medicine
