摘要
大规模的全基因组测序计划正产生越来越多的序列信息,而理解这些信息的关键是理解基因产物——蛋白质的功能。在后基因组时代,蛋白质的三维结构解析是揭示生命密码的重要部分。随着技术进步和大量来自公共机构和私人企业的资金投入,结构蛋白质组学研究开始启动,它的目标是采用工业化生产的方式在基因组规模去大量测定蛋白质的结构。这将会改变结构生物学家的研究方式。蛋白质结构测定的流程,从cDNA的克隆到数据收集,大部分将实现自动化。结构蛋白质组学是实验和理论计算相结合的多学科交叉的领域。目前,结构蛋白质组学仍然面临着许多技术上的挑战,这些挑战也带来了很多机遇。结构蛋白质组学产生的大量结构信息将是一笔巨大的财富,它将给制药行业带来重大变化。近年来,基于蛋白结构的合理药物设计在制药行业非常流行。同时,它也必将给生物学领域带来一场革命。
The genome-sequencing projects are providing more and more sequence information across all living organisms. A key to comprehending the sequence information is understanding the function of each protein, which is the product of the gene. Structural descriptors for proteins arecrucial for unlocking the secrets in the functional genomic era. With recent technological advances and great funding from both public and private sources, new initiatives in Structural Proteomics which aim to determine largely protein structures on a genome scale in Protein Structure Factories will change the way structural biologists work. Determining protein structures will largely be automated from cDNA cloning to collection of data. Structural Proteomics demands collaborative effort of the talents of many experimental and computational researchers, and cooperation from different disciplines. Structural Proteomics brings a revolution from cottage industry to machine industry in the field of structural biology. But there are still many technological challenges in Structural Proteomics that remain to be solved. The enormous wealth of structure data that is provided by Structural Proteomics will revolutionize biology and pharmacy in which the rational drug design based on protein structures has been very prevalent in recent years.
出处
《中国基础科学》
2001年第1期26-32,共7页
China Basic Science
基金
国家自然科学基金
"863"计划
"973"计划资助
