摘要
目的 :分析肾虚型排卵障碍或着床失败引起的不孕的中医药研究的方法和思路。方法 :从卵泡生长发育相关因素如IGF - 1mRNA、EGFmRNA ,卵泡基质崩解相关因素如MMPsmRNA、PAmRNA、PAI- 1mRNA等相关因素 ,以及与着床粘附有关的内膜细胞整合素β3mRNA表达等角度 ,探讨中医药治疗不孕的可能分子机制 ,并且各因素之间存在互动关系。结果 :补肾或补肾化瘀方药可能通过促进卵泡发育成熟 ,并诱发成熟卵泡破裂 ,稳定子宫内膜有利于孕卵着床等角度防治不孕。结论 :中医药治疗排卵障碍或着床失败所致不孕具有传统优势 ,提取分离补肾或补肾化瘀方药有效成分 ,从分子水平探讨中药复方有效成分对各指标互动关系影响作用 ,不孕研究可能取得重要进展。
Objective: To analyse the method and thinking of TCM investigation about alloovulation or failed imbed in infertility with kidney deficiency. Method: To study the possible molecul mechanism about TCM in treating infertility and mutual relations among factors through invesigate related factors of follioular growth and development like IGF-1 mRNA?EGF mRNA, related factor of follioular stroma disintegrate like MMPs mRNA, PA mRNA, PAI-1 mRNA, and expression of endomorph cell integrin β 3 mRNA related to imbed and adhesiveness. Result: Busheng or Bushenghuayu Chinese herbal medicines possible prevent and cure infertility by means of accelerating ovi-bleb's auxano and maturity, evoking mature follicle's disruption and labiling endometrium to ovi-pregnant's imbed. Conclusion: TCM has traditional superiority on alloovulation or failed imbed in infertility, investigation with infertility perhaps has important progress by means of extracting utility component of Busheng or Bushenghuayu midicines and exploring effects of utility component of Chinese herbal recipe on mutual relation among parameters.
出处
《中医药学报》
CAS
2002年第1期4-5,共2页
Acta Chinese Medicine and Pharmacology
基金
湖南省教委科研基金资助项目
关键词
不孕
肾虚证
基质金属蛋白酶类
生长因子
整合系β3
纤溶酶原激活剂
纤溶酶激活抑制剂
中医药疗法
infertility
kidney deficiency
ovulation
matrixmetalloproteinase(MMPs)
growth factor(EGF, IGF-1)
integrin β3
plasminogen activating dose(PA)
plasminogen activating inhibitor(PAI)
traditional Chinese medicine therapy
