摘要
应用了 ECP FEI荧光酶标法检测了 32例典型慢性荨麻疹患儿及 13名正常儿童的血清嗜酸细胞阳离子蛋白 (ECP)值，同时还检测了患儿和正常儿童血清总 IgE值及外周血嗜酸粒细胞 (EOS)计数，并比较了它们之间的联系。结果显示：患儿血清 ECP值为 12.96± 9.72μ g/L、血清总 IgE值为 970.10± 312.61IU/mL，二者均明显高于正常对照组 (P< 0.05)；而患儿的血 EOS计数与正常儿童相比增高不明显 (P >0.05)。慢性荨麻疹患儿血清 ECP和血清总 IgE与外周血 EOS计数之间无相关性。提示儿童慢性荨麻疹中血清 ECP和血清总 IgE的变化可能较血 EOS计数变化更灵敏，更能反映 EOS的活化程度。
In this study, serum ECP was measured with pharmacia CAP ECP in children with chronic urticaria patients(n=32) and health controls(n=13). Blood eosinophil count and total serum IgE were examined at the same time. Their interrelation was compared. The results showed that the mean levels of serum ECP and Serum IgE in 32 children with chronic urticaria were 12.96± 9.72μ g/L and 970.10± 312.61mg/L, respectively. They were both significantly higher than that from healthy controls(P< 0.05), but blood eosinophil count showed no significant change(P >0.05). There was no significant correlation between serum ECP,total IgE and blood eosinophil count in chronic urticaria childern. The results suggest that the change of serum ECP and total IgE is more sensitive than the change of blood eosinophil count. It is better to reflect the degree of activation of eosinophil.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2001年第4期218-219,共2页
Journal of Clinical Dermatology
