摘要
本文研究小鼠小肠上皮细胞分割照射时亚致死性损伤修复的特点。定量测定每次照射后修复的剂量(D_R值)。结果见到D_R的大小与照射的剂量有关。但每次照射后修复的百分比(F_R)均为50％左右。STRANDQVIST曲线指出其修复斜率为0.25。这和皮肤等组织相似。应用线性—平方概念(L-Q模式)分析了细胞生存数为20时的等效总剂量,求得小肠上皮细胞的α/β比值为10.7Gy。
Repair characteristics of intestinal epithelium has been investigated after 1, 2, 3, 4, 6 and 10 fractionated 60Co γ-Ray irradiations.Quantitative estimation of repair of sublethal injury per fractional interval, expressed as (Dn- D1)/(n-1), related to size of the dose is dosedependent. But the average of each fractional dose approximated 50%.The iso-effect data correlated well with the Linear-Quadratic equation, in which the ratio of linear to quadratic coefficients(α/β) was 10.7 Gy. This is in the range of published α/β values for early reaotong tissues.
出处
《上海医科大学学报》
CSCD
1991年第1期23-26,共4页
Journal of Fudan University(Medical Science)
关键词
小肠上皮细胞
损伤
亚致死性
修复
intestine epithelium
sublethal damage repair
L-Q model
