摘要
目的 探讨北京市大饭店中央空调系统与军团菌感染相关关系。方法 随机抽取北京市 4家大饭店 414位工作人员作为暴露人群和 414位对照者作为对照人群 ,用历史性队列研究方法 ,针对中央空调系统这一暴露因素进行血清流行病学研究。结果 暴露人群与对照人群军团菌抗体总阳性 (人年 )率分别为 11 5‰和 2 1‰ (χ2 =38 2 ,P <0 0 1,RR =5 48,AR % =81 8% )。通过年龄分层分析 ,暴露人群各年龄组抗体阳性 (人年 )率明显高于对照人群 ,其中差异最大的是 <35岁年龄组。比较暴露人群与对照人群Lp1～Lp14抗体滴度水平 ,暴露人群Lp1、Lp6、Lp12、Lp144个菌型高于对照人群。对暴露人群感染水平与暴露时间进行趋势性卡方检验 (χ2 =0 5 9,P =0 75 ) ,没有显示出暴露人群感染水平随着暴露时间的延长而且上升趋势。
A historical cohort study was carried out by comparing levels of sero antibodies against Legionella pneumnophila of 414 workers who were taken as the exposure group under central air conditioning systems with 414 controls from the general poputation as the non exposure group.The results showed that the positive rates(persons time) of sero antibodies against Lp1 14 from both of above two groups were 11.5‰ and 2.1‰ respectively.The positve rate of the former was rather higher than that of the latter.(χ\+2=14.2 p<0.01,RR=5.48,AR%=81.8%).By means of stratified analysis, it was shown that each of positive rate of different age groups of the exposure group was higher than that of the non exposure group, with the most different in <35 age group(χ\+2=14.4,P<0.01, RR=17.0, AR%=94.1%). As compared with the non-exposure group, the titer of Lp1, Lp12, and Lp14 of the exposure gorup were significantly higher than that of the non-exposure group.However, it was also shown that, by tendency of examination, the positive rate in exposure group was no longer increase with exposure time went on (χ\+2= 0.59, P=0.75). The results suggested that the central air conditioning system should be a potential risk factor for legionnaires' disease.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2001年第2期122-123,共2页
Chinese Journal of Public Health
关键词
中央空调系统
军团菌感染
队列研究
central air conditioning system
legionellosis
historical cohort study
