摘要
目的 :探讨影响鼻咽癌放射治疗远期疗效的主要因素及死亡的主要原因。方法 :对 1988～1990年 ,我院首程治疗随访 10年以上的 185例鼻咽癌进行回顾性分析 ,主要讨论 10年生存率与性别、年龄、病理类型、临床分期、T、N期别、照射剂量间的关系及影响预后的主要因素。结果 :总 10年生存率(OS)为 34 6% ,Ⅰ～Ⅱ期分别为 75 0 %、5 8 5 %、37 3%、10 5 %。 10年无局部区域复发生存率 (LRE)为 5 9 7% ,10年无远地转移生存率 (DMF)为 5 8 9%。局部区域复发率 33 0 % (61/ 185 ) ,远地转移率30 3% (5 6/ 185 ) ,因复发和远地转移死亡占总死亡率为 86 8% (10 5 / 12 1)。 10年生存率与临床分期 ,T、N期别明显相关 (P <0 0 1) ,与年龄 ,放射剂量关系有统计学意义 (P <0 0 5 ) ,与病理类型 ,性别无关 (P>0 0 5 )。结论 :临床分期是影响远期疗效的主要因素 ,早期根治性放射治疗是提高生存率的关键 ,远处转移和局部区域复发是鼻咽癌致死的主要原因 ,放射剂量以 70～
Objective To evaluate the main factors of influencing Nasopharyngeal Carcinoma long time result and the main cause of failure.Methods The relationship between 10 year survival rate and age,sex,histological type,clinical stage and radiation doses were analysis retrospectively for 185 patients with NPC treated from 1988 to 1990 in our hospital.Results The overall 10 year survival rate (OS) was 34.6%,Ⅰ,Ⅱ,Ⅲ and Ⅳ stage were 75.0%,58.5%,37.3% and 10.5% respectively.The 10 year local relapse free survival (LRF) was 59.7% and the 10 year distant metastasis free survival (DMF) was 58.9%.The local relapse recurrence rate was 33.0% and the distant metastasis rate was 30.3%.Of the 121 patients who died,both recurrence and distant metastasis was 86.5% (105/121).The 10 year survival rate has a strong association with the clinical stage,T,N stage,age and dose but the relationship between the histological type and sex is rarely eminent.Conclusions The clinical stage was the most prognostic.Early radiotherapy is the key which can increase the survival rate.The distant metastasis and local recurrence are the main cause of failure.The optimal dose of the primary focus is 70～80 Gy.
出处
《肿瘤防治杂志》
2001年第6期631-633,共3页
China Journal of Cancer Prevention and Treatment
关键词
鼻咽肿瘤
放射疗法
随访
回顾性研究
nasopharyngeal neoplasms/radiotherapy
follow up
retrospectively studied
