摘要
目的 比较正常与异常妊娠妇女的主要脂类代谢指标 ,以探讨血脂测定在预示异常妊娠中的价值。方法 采用东芝TBA30FR全自动生化分析仪测定了 389例正常孕妇 ,5 8例妊娠高血压综合征 (妊高征 )、2 3例宫内生长迟缓 (IUGR)和 2 5例先兆早产病例的甘油三酯 (TG)、总胆固醇 (TC)、高密度脂蛋白胆固醇 (HDL C)、低密度脂蛋白胆固醇 (LDL C)、载脂蛋白AI(ApoAI)、载脂蛋白B(ApoB)。 结果 异常妊娠时 ,各项脂类代谢指标 ,显著不同于同期正常妊娠妇女。妊高征组 :TG升高 ,HDL C、ApoAⅠ下降明显 ,LDL C/HDL C显著升高而ApoAI/ApoB下降。先兆早产组 :TG、TC、HDL C、ApoB、LDL C均明显下降 (P <0 .0 0 1) ,而ApoAⅠ改变不明显 ,ApoAⅠ /ApoB则明显升高。IUGR组 :主要表现为TG、TC、ApoB、LDL C和HDL C明显下降 ,ApoAⅠ改变不明显 ,ApoAⅠ /ApoB则明显升高。 结论 :妊高征脂类代谢异常主要表现为血清中脂蛋白亚组分改变 ,致动脉粥样硬化的危险因素增加 ,可能是促成妊高征胎盘血管病变的原因之一。IUGR、先兆早产等异常妊娠时 ,多项脂类代谢水平的下降 ,间接或直接地影响了类固醇激素的合成与代谢 ,可能是引发IUGR、先兆早产的重要因素。
Objective To investigate the differences in serum lipid, lipoprotein and apolipoprotein concentrations in normal and pregnancy-induced hypertension(PIH), intrauterine growth reterdation (IUGR) and premature delivery pregnant women. Methods Serum cholesterol(TC), triglycerides (TG), high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C),apolipoprotein A1(ApoAⅠ),apolipoprotein B (ApoB) concentrations were measured in 495 pregnant women (389 cases of the normal, 58 PIH, 23 IUGR and 25 premature delivery)in the third trimester of pregnancy. Results\ Abnormal pregnant women showed a different serum concentrations of lipid, lipoprotein and apolipoprotein: Higher TG, Lower HDL-C and ApoA1, higher ratio of LDL-C/HDL-C and lower ApoA/ ApoB in PIH; significantly decreased TG,TC,HDL-C,ApoB,LDL-C, the same ApoAⅠand significantly raised ApoAⅠ/ApoB in premature delivery patients.While TG,TC,ApoB,LDL-C and HDL-C were significantly low, but ApoAI were not different compared to those in the normal group and ApoAⅠ/ApoB were raised significantly in IUGR patients. Conclusion In abnormal pregnancy,such as PIH , the serum lipid, lipoprotein and apolipoprotein concentrations were changed compared to the normal, which increases the risk of subsequent atherosclerosis and decreased the factors protecting artery from atherosclerosis. This may be one of the causes of inducing placenta artery atherosclerosis in PIH. In IUGR and premature delivery group, the decreased level of different serum concentrations of lipid,lipoprotein and apolipoprotein will directly and indirectly affect the synthesis and metabolism of cholesterol hormones, affect the growth of fetal and the functions of placent, which may be the important factor inducing the IUGR and premature delivery.
出处
《中国实验诊断学》
2001年第4期171-174,共4页
Chinese Journal of Laboratory Diagnosis
关键词
血脂
胎儿宫内生长迟缓
妊娠高血压综合征
Serum
lipid
Intrauterine growth reterdation (IUGR)
Pregnancy-induced hypertension(PIH)
