摘要
目的 观察舒林酸对散发性结直肠腺瘤的疗效。方法 3 6例经结肠镜和组织学诊断的散发性结直肠腺瘤病人 ,随机分为二组 ,治疗组口服舒林酸 4 0 0mg/d ,对照组口服安慰剂 2片 /d ,疗程均为 4个月。观察治疗前和治疗 4个月时腺瘤数目、最大直径、形态及腺瘤异型增生分级变化。结果 治疗组和对照组各 16例完成试验。治疗前、后比较 ,治疗组 5 9个腺瘤直径分别为 ( 3 .6± 2 .2 )和 ( 2 .4±1.5 )mm ,治疗后腺瘤直径较治疗前明显缩小 ,差异有非常显著性 (P <0 .0 0 1) ;腺瘤形态较治疗前变化明显 ,出现扁平隆起和红斑。异型增生级别明显降低 ,差异有非常显著性 (P <0 .0 0 1) ;对照组 3 0个腺瘤直径分别为 ( 4 .6± 2 .5 )和 ( 3 .7± 2 .2 )mm ,差异无显著性 (P >0 .0 5 )。腺瘤形态和异型程度无明显变化。结论 舒林酸可使散发性结直肠腺瘤直径缩小甚至消退 ,并使腺瘤异型程度降低。舒林酸对散发性结直肠腺瘤治疗有效。
Objective To investigate the effects of su lindac on sporadic colorectal adenomas. Methods Thirty-six patients diagnosed as sporadic colorect al adenomas colonoscopically and pathologically were randomly divided into t wo groups. The study group took 400 mg of sulindac daily and the control group w ere given placebo both for 4 months. Changes of number, size, figure and degree of atypia of adenomas were compared before and after treatment. Results Sixteen patients in each group finished the trial. In the study group, the average diameter of 59 adenomas before and after the treatment was (3.6±2.2) mm and (2.4±1.5) mm, respectively. The difference was statist ica lly significant (P<0.001). The figure of adenomas changed significantly, including flat protuberance, erythema, etc. The degree of atypia of adenomas di mi-(nished (P<0.001).) In the control group, the average diameter of adenomas before and after treatment was (4.6±2.5) m m and (3.7±2.2) mm respectively. There was no significant diference (P>0.05) nor were the changes in figure and degree of atypia of adenomas. Conclusions Sulindac is effective in the reduction of size and a typ ia degree of adenomas in patients with sporadic colorectal adenomas but the long term effects of sulindac in patients with sporadic colorectal adenomas should b e observed.
出处
《中华消化杂志》
CAS
CSCD
北大核心
2001年第12期710-712,共3页
Chinese Journal of Digestion
