摘要
目的 观察氨碱茶对老年人淋巴细胞增殖及凋亡的影响。方法 选取 34例健康老年自愿者 ,进行了 3种不同剂量口服氨茶碱试验 ,并设正常组做对照。结果 小剂量组 (0 .1 2 5 mg/ kg)对免疫功能有明显的促进作用 ,进一步探讨发现小剂量茶碱可促进 B淋巴细胞增殖 (P <0 .0 5) ,对 T细胞增殖无影响 ,小剂量茶碱对 PHA刺激后的 T淋巴细胞的凋亡有明显的抑制作用 (P <0 .0 5)。
? Objective To evaluate the immunoloregulation effect of aminophylline in the aged. Methods 24 elderly healthy volunteers were intravenously dripped with 3 different doses of aminophylline and 10 controls with saline for 40 days, respectively, and the lymphocyte proliferation and lymphocyte apoptosis were determined. Results Our results show that small dose aminophylline (0.125 mg/kg) have obvious promotion on immunological function, in which it can accelerate B lymphocytes to proliferate (P<0.05), but have no influence on T lymphocytes. In addition, small dose of aminophylline have transparent inhibition on the apoptosis of T lymphocytes irritated by PHA (P<0.05). Conclusion Small dose of aminophylline has obvious promotion on the lymphocytes in the aged.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2001年第6期427-428,共2页
Chinese Journal of Gerontology
