摘要
目的 :观察降纤酶治疗急性缺血性脑梗死的临床疗效及其对促肾上腺皮质激素 (ACTH)、皮质醇 (CS)的影响 ,探讨其作用机理和临床意义。方法 :采用放射免疫分析 (RIA)法对该药治疗前后上述指标含量进行检测 ,并与健康人作对照。结果 :治疗后 ACTH、CS与治疗前比较均有明显的降低 (P<0 .0 1)。结论 :急性脑梗死患者高 ACTH、CS变化与缺血性脑梗死有密切关系 ,认为可作为判断病情与转归的重要指标。此外 ,降纤酶除了抗凝溶栓外 ,尚可能与其调整下丘脑 -垂体 -肾上腺皮质轴神经内分泌功能有关。
Objective:To observe the clinical efficacy of cellulase in treating acute cerebral infarction and the influence of adrenocorticotropin (ACTH) and cortisole so as to explore the effects and mechanisms. Methods:Detections were made on the serum cellulase levels by using radioimmunoassay in pre and post operative conditions and comparisom was made with the healthy control cases. Results:After the treatmen,the ACTH and cortisole leve1s were greatly reduced when compared with the control( P < 0.01 ). Conclusions:The higher 1evels of ACTH and cortiso1e was c1osely related to the acute cerebral infarction and it could be used as an index for the diagnosis and prognosis. Cellulase might also regulate the hypothalamus pituitary cortex neurosecretions.
出处
《浙江中西医结合杂志》
2001年第10期601-602,共2页
Zhejiang Journal of Integrated Traditional Chinese and Western Medicine
