摘要
目的 观察清远市地区产超广谱 β-内酰胺酶 (ESBL s)大肠埃希菌的耐药性和流行情况 ,指导临床用药。方法 应用 Micro Scan Auto SCAN- 4、专用 NC2 1鉴定板检测 180例大肠埃希菌 ESBL s的产生和其体外对抗生素的耐药性。结果 产 ESBL s大肠埃希菌阳性率 5 1.1% ,以儿科 (10 0 % )最高、重症监护病房 (81.8% )次之 ,对头孢菌素类、氨苄西林、哌拉西林、环丙沙星、妥布霉素、复方新诺明呈多重耐药、耐药率 42 .4%～ 91.3% ,显著高于非产 ESBL s大肠埃希菌 (P<0 .0 5～ 0 .0 1) ;对亚胺培南、哌拉西林 /三唑巴坦具有高敏感性。结论 清远地区具有较高的产 ESBL s大肠埃希菌检出率 ,对于产 ESBL s大肠埃希菌应用亚胺培南、哌拉西林 /三唑巴坦等含
Objective To observe the resistance and the prevalence of Escherichia coil strains producing Extended Spectrum β lactamases(ESBLs) in Qingyuan region in order to pave the way for clinical correct use of drugs.Methods 180 Escherichia coils were examined whether producing ESBLs or not and antibiotic resistance tests in vivtro were performed by NC 21 board of MicroScan AutoSCAN 4.Results The ESBLs positive rate was 51.1% with departmemt of pediatric(100%) and ICU(81.8%) being the top two.The ESBLs producing strains showed resistance to tocephalosporins,ampicillin,piperacillin,ciprofloxacin,tobiamycin,trimethoprim/sultamethoxazole with rates ranging from 42.4%～91.3%,significantly higher than strains not producing ESBLs(P<0.05～0.01).ESBLs producing strains showed high susceptivity to imipenem and piperacillin/tazobac.Conclusions The isolating rate of ESBLs producing Escherichia coil strains in Qingyuan region was pretty high.Combined antibiotics containing β Lactama/β Lactamase inhibitor such as imipenem,piperacillin/tazobac were effective to ESBLs producing Escherichia coil strains.
出处
《中国误诊学杂志》
CAS
2002年第2期194-196,共3页
Chinese Journal of Misdiagnostics
