摘要
【目的】检测正常子宫内膜、增生过长子宫内膜及子宫内膜癌组织中一氧化氮合酶 (NOS)的活性比 ,探讨NOS与子宫内膜癌间的关系。【方法】NOS活性及蛋白含量均用美国BACKMAN公司的核酸及蛋白分析仪检测。【结果】子宫内膜癌组织中一氧化氮合酶含量显著增高 (P <0 0 1) ,而增生过长子宫内膜和正常子宫内膜相比NOS含量无显著差异 (P >0 0 5 ) ,子宫内膜癌组织中 ,随分化程度的降低 ,NOS含量增多 (P <0 0 0 1) ,与恶性程度呈正相关。【结论】一氧化氮合酶含量的增多可能是子宫内膜癌发生及生长过程中的一个值得注意的因素。子宫内膜癌组织中NOS增高可能是NO合成增多的原因之一。
To study the relationship between nitric oxide synthase (NOS) and endometrium neoplasma by comparing the activity of NOS in nomal endometrium carcinoma tissue, endometrial hyperplasia and endometrium carcinoma tissue. Nucleic acid and protein analyzer were used to examine the activity of NOS. The activity of NOS was significantly higher in endometrium carcinoma tissue than that in normal endometrium tissue and endometria hyperplasia tissue (P<0 05). The activity of NOS increased with the low differentiating degree of the tumor (P<0 05). [Conclusion] The study suggests that NO produced by activated madcrophagocytes in the tumor tissue may play a role of immunomodulation. The increase of NOS may be a factor which is to be emphasized in endometrium neoplasm.
出处
《中山医科大学学报》
CSCD
北大核心
2001年第6期473-475,共3页
Academic Journal of Sun Yat-sen University of Medical Sciences
基金
中山医科大学孙逸仙纪念医院科研基金项目 (F0 0 2 0 0 0 0 99)
