摘要
【目的】观察大孔高吸附表面积高分子吸附剂对尿毒症中分子物质的清除效果。【方法】用大孔高吸附表面积高分子吸附剂型吸附器与透析器串联 ,对 30例慢性尿毒症患者作单次吸附 透析治疗 ,并与血液透析作交叉对照 ,观察治疗前后中分子物质的清除差异。【结果】治疗后吸附 透析组和血液透析组中分子物质均有所降低 ,但吸附 透析组降低比血液透析组差异显著 (P <0 0 5 ) ;两组对尿素氮和肌酐的清除率比较差异不显著 (P >0 0 5 )。治疗后两组血浆白蛋白、球蛋白、红细胞、血色素、白细胞、血小板和电解质的改变差异均不显著 (P >0 0 5 )。【结论】吸附比透析能更有效清除尿毒症病人体内的中分子物质 ,与透析联合应用可提高治疗效果。
To investigate the effect of removing middle molecular substance (MMS) with high surface area adsorba big hole high polymer absorbers in uremia patients. Thirty selected uremic patients were treated with the absorber and dialyzer in series (hemoperfusion hemodialysis) for one single session and received hemodialysis as the cross control. The changes of MMS during hemoperfusion hemodialysis and hemodialysis were observed. As compared with the beginning of treatments, MMS in participates were decreased at the end of the treatment both in hemoperfusion hemodialysis and hemodialysis groups; but the changes in the former were greater than in the latter (P<0 05). There were no different in Urea and creatinine clearances between the two groups (P>0 05). And as to plasma albumin, globulin, erythrocyte, hemoglobin, leukocyte, platelet and electrolyte, there were also no significant changes both during hemoperfusion hemodialysis and hemodialysis (P>0 05). [Conclusions] AP was more effective to remove MMS in uremia patients than HD, and the effect could be improved if making absorber and dialyzer in series.
出处
《中山医科大学学报》
CSCD
北大核心
2001年第6期466-467,472,共3页
Academic Journal of Sun Yat-sen University of Medical Sciences
