摘要
以甲二醇二对甲苯磺酸酯和重氮乙酸乙酯为起始原料 ,经取代、还原、甲基化、磷酸化反应合成了 5个氟代胆碱类化合物 ,经1H NMR及质谱确证了结构 ,并进行了抗肿瘤活性的细胞筛选实验。结果表明这 5个化合物均具有一定的抗肿瘤活性。其中FC 3对 4种癌细胞均具有较好的抑制作用 。
Five fluorocompounds were synthesized from ethyl diazoacetate or methanediol bis(4 methylbenzene sulfonate) via substitution,reduction,methylation and phosphatization. Their structures were identified by MS and 1H NMR . All of them showed anti tumor activities. In particular, compound FC 3 showed better inhibition activities to four cancer cells and it's worthy of further screening.
出处
《沈阳药科大学学报》
CAS
CSCD
2001年第6期411-413,共3页
Journal of Shenyang Pharmaceutical University
