摘要
目的 研究血清中可溶性血管细胞粘附分子 (sVCAM 1)的含量在胃癌诊断及复发中的意义。方法 用酶联免疫吸附试验测定 2 5例正常人、30例胃癌病人术前未作任何治疗及术后一周无感染血清中sVCAM 1的浓度 ,研究其浓度与胃癌的临床、病理的关系。同时测定TSGF及CEA作为对照。结果 胃癌患者血清中sVCAM 1比正常对照组明显增高 ,差异有显著性 (P <0 0 1) ;术前、术后血清中sVCAM 1浓度有显著性差异 ,术后血清sVCAM 1浓度下降 (P <0 0 1)。结论 sV CAM
Objective To study the correlation of serum concentration of sVCAM-1 to gastric cancer.Methods The serum levels of soluble VCAM-1 were measured with sandwith enzyme immunoassay in 25 normal people and 30 patients with stomach neoplasms before treatment and after operation.Meanwhile TSGF and CEA were also examined.Data were collected on tumour stage at presentation,presence and sites of metastatic disease,tumour pathology.Results Serum concentrations of VCAM-1,TSGF,CEA were elevated in the patients with gastric cancer in comparison with a group of healthy subjects (P<0.001).A correction was also found between the concentration of VCAM-1 and the depth of tumour infilitration.Conclusion The measurement of circulating VCAM-1 may be regarded as an effective prognostic factor for patients with gastric cancer.
出处
《江苏医药》
CAS
CSCD
北大核心
2002年第1期12-14,共3页
Jiangsu Medical Journal
