摘要
目的 维甲酸类药物是治疗银屑病的有效药物 ,芳维甲酸乙酯是第三代维甲酸的代表之一 ,其治疗指数是第一代维甲酸的 10倍。本研究的目的是估价芳维甲酸乙酯治疗中至重度斑块性寻常型银屑病的疗效及其安全性。方法 用芳维甲酸乙酯治疗 187例中、重度斑块性寻常型银屑病 2月。以PASI指数作为估价病情程度的指标 ,治疗前后皮损做病理检查 ,对芳维甲酸乙酯的疗效及安全性进行评估。结果 187个病例中有 16 8例的PASI指数显著降低 :其中 81例痊愈 ,5 3例显效 ,34例有效 ,19例无效 ,总有效率达到 89 8%。副作用轻微。
Objective Arotinoids is an effective treatment for psoriasis Arotinoid ethylester(RO13 6298) belongs to the third generation of retinoic acid derivatives and its treat index is ten times of the first generation retinoids The objective of this study was to evaluate the efficacy and safety of arotinoid ethylester on moderate to severe plaque type psoriasis Methods One handred and eighty seven patients with moderate to sever plaque type psoriasis were treated with arotinoid ethylester for two month The clinical disease was assessed by the PASI index Biopsy specimens obtained from lesional skin before treatment and after 1 month of treament were examined using histochemical Results After two month of treatment,PASI index in 168 of 187 patients marked descended:81(43 3%) patients were cured,53(28 3%)excellent.34(18 2%)good and 19(10 1)did not respond to treatment The side effects were slight Conclusion Arotinoid ethylester is effective and safe for the treatment of moderate to severe plaque type psoriasis The mechanism of action of this drug seems to be the induction of apoptosis in activated T lymphocytes
出处
《重庆医学》
CAS
CSCD
2002年第2期100-101,共2页
Chongqing medicine
