摘要
目的 探讨耳鼻喉神经内分泌癌的临床病理特征 ,对其诊断和鉴别诊断进行了讨论。方法 收集 13例耳鼻喉神经内分泌癌 ,观察其临床病理特点并进行免疫组化分析。结果 13例中男性 9例 ,女性 4例 ,平均年龄4 3 5岁 ,临床经过呈侵袭性。其中不典型类癌 1例 ,大细胞神经内分泌癌 5例 ,小细胞神经内分泌癌 7例。肿瘤细胞CK、EMA、CEA、CgA、Syn、NSE、Sero均呈阳性表达。结论 耳鼻喉神经内分泌癌为一种极少见的肿瘤 ,根据其组织学改变和免疫组化染色结果 ,可与其他头颈部肿瘤鉴别。
Objective To study the clinicopathological features of neuroendocrine carcinomas (NEC) of the head and neck, and to elucidate its diagnosis and differential diagnosis. Methods The clinical data were reviewed retrospectively and immunohistochemical stains were performed in 13 cases of NEC. Results here were 9 male and 4 female with average age of 43.5 years. The course of the disease was aggressive. Three histological types were found: atypical carcinoid (1 case), large cell type (5 cases) and small cell type (7 cases). The tumor cells were positive for CK, EMA, CEA, CgA, Syn,NSE and Sero.Conclusions NEC of the head and neck is a rare tumor. It can be differentiated from other head and neck tumors based on the histopathologic features and immunohistochemical findings. Histological type of the tumor is important for clinical therapy and prognostic evaluation.
出处
《诊断病理学杂志》
CSCD
2002年第1期12-14,T003,共4页
Chinese Journal of Diagnostic Pathology
