摘要
目的 :测定并比较左氟沙星 (LVFX)、氧氟沙星 (OFLX)和环丙沙星 (CPLX)对 19例行胆管引流患者的血清和胆汁杀菌效价。方法 :采用微量平板稀释法测定杀菌效价。结果 :LVFX对大肠杆菌、链球菌、变形杆菌、金葡球菌的杀菌效价最高 ,OFLX对变形杆菌、链球菌的杀菌效价较高 ,CPLX仅对变形杆菌有效 ,3种药物对绿脓杆菌的作用弱。结论 :对于胆道常见致病菌感染 。
OBJECTIVE:Serum bactericidal activity(SBA) and bile bactericidal activity(BBA) of Levofloxacin(LVFX)?Ofloxacin(OFLX) and Ciprofloxacin(CPLX) were determined and compared in 19 patients underwent biliary duct drainage. METHODS: Broth microdilution method was used to determined SBA and BBA. RESULTS: SBA and BBA of LVFX were the highest against E.coli?Streptococcus?Proteus and S.aureus; SBA and BBA of OFLX were relatively high against Proteus and Streptococcus; the activity of CPLX was high only against Proteus; three drugs were low against P. Aeruginosa. CONCLUSION: The effect of LVFX in biliary tract infection was higher than that of OFLX and CPLX.
出处
《华西药学杂志》
CAS
CSCD
2001年第6期436-437,共2页
West China Journal of Pharmaceutical Sciences
关键词
血清杀菌效价
胆汁杀菌效价
左氟沙星
氧氟沙星
环丙沙星
Serum Dactericidal activity
Bile bactericidal activity
Levofloxacin
Otloxacin
Ciprotloxacin
